Infertility may be passed on to their offspring in a small proportion of men and women.
Among males, genetic conditions like Klinefelter syndrome or microdeletion in AFZ (azoospermia factor C) may be hereditary.
While in the past these men were permanently infertile, with the advancement in artificial reproductive techniques, men with azoospermia, a medical condition of a male not having any measurable level of sperm in his semen, may now become fathers. However, the infertility may still be passed on to the next generation.
Other conditions like cystic fibrosis may also cause infertility.
Among females, polycystic ovarian syndrome, which is an important cause of infertility, may be genetically inherited in some families.
This fertility special is contributed by the NUH Women’s Centre, National University Hospital. Please visit www.nuhgynae.com.sg to read more.